Vendredi 19 avril 2019
| Port Vale | 1-4 | Stevenage |
| Lyon | 2-1 | Angers |
| Dijon | 3-2 | Rennes |
| Le Havre | 2-1 | Paris FC |
| Sparta | 3-1 | Helmond |
Samedi 20 avril 2019
| Borussia | 1-2 | Leipzig |
| Admira | 2-1 | Hartberg. |
| Wolver. | 0-0 | Brighton |
| C.Bruges | 1-2 | Courtrai |
| Grenoble | 0-2 | Lens |
| Parme | 1-1 | Milan |
| Lazio | 1-2 | Chievo |
