Vendredi 15 mars 2019
| Lille | 0-1 | Monaco |
| Châteauroux | 0-1 | Paris FC |
| Fortuma | 3-1 | FC Emmen |
| UtrechtII | 1-3 | Eindhoven |
| MVV | 1-4 | RKCW |
Samedi 16 mars 2019
| Hertha | 2-3 | Dortmund |
| Hull City | 2-2 | Queens |
| Nîmes | 2-2 | Strasbourg |
| Hellas | 1-1 | Ascoli |
| Breda | 0-4 | Utrecht |
| Ural | 0-1 | CSKA |
| Akhisar | 2-3 | Kasimpasa |
